About
Titles
Postdoctoral Fellow
Biography
Dr. Greaney is an NRSA Postdoctoral Fellow (NHLBI) jointly mentored by Dr. Ruslan Medzhitov at Yale and Dr. Robert Langer at MIT. Her research leverages engineered whole-lungs as highly biomimetic tissue models for studying pulmonary development, homeostasis, and disease. She has further developed advanced computational methodologies for evaluating scRNAseq data from engineered tissues. She previously earned her doctorate in the lab of Dr. Laura Niklason at Yale.
Education & Training
- NRSA Postdoctoral Fellow
- Yale School of Medicine
- NRSA Postdoctoral Fellow
- Massachusetts Institute of Technology
- PhD
- Yale University, Biomedical Engineering (2021)
- BS
- Tufts University, Biomedical Engineering (2015)
Research
Publications
Featured Publications
SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection
Greaney A, Raredon M, Kochugaeva M, Niklason L, Levchenko A. SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection. IScience 2023, 26: 106175. PMID: 36788793, PMCID: PMC9912025, DOI: 10.1016/j.isci.2023.106175.
Peer-Reviewed Original Research
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Concepts
Decellularization compromises mechanical and structural properties of the native trachea
Greaney A, Ramachandra A, Yuan Y, Korneva A, Humphrey J, Niklason L. Decellularization compromises mechanical and structural properties of the native trachea. Biomaterials And Biosystems 2023, 9: 100074. PMID: 36967724, PMCID: PMC10036236, DOI: 10.1016/j.bbiosy.2023.100074.
Peer-Reviewed Original Research
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Concepts
The History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future
Greaney A, Niklason L. The History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future. Tissue Engineering Part B Reviews 2020, 27: 341-352. PMID: 33045942, PMCID: PMC8390779, DOI: 10.1089/ten.teb.2020.0238.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing
Greaney AM, Adams TS, Raredon M, Gubbins E, Schupp JC, Engler AJ, Ghaedi M, Yuan Y, Kaminski N, Niklason LE. Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing. Cell Reports 2020, 30: 4250-4265.e6. PMID: 32209482, PMCID: PMC7175071, DOI: 10.1016/j.celrep.2020.03.004.
Peer-Reviewed Original Research
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MeSH Keywords and Concepts
2023
Rational engineering of lung alveolar epithelium
Leiby K, Yuan Y, Ng R, Raredon M, Adams T, Baevova P, Greaney A, Hirschi K, Campbell S, Kaminski N, Herzog E, Niklason L. Rational engineering of lung alveolar epithelium. Npj Regenerative Medicine 2023, 8: 22. PMID: 37117221, PMCID: PMC10147714, DOI: 10.1038/s41536-023-00295-2.
Peer-Reviewed Original Research
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Concepts
2022
Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome
Raredon MSB, Yang J, Garritano J, Wang M, Kushnir D, Schupp JC, Adams TS, Greaney AM, Leiby KL, Kaminski N, Kluger Y, Levchenko A, Niklason LE. Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome. Scientific Reports 2022, 12: 4187. PMID: 35264704, PMCID: PMC8906120, DOI: 10.1038/s41598-022-07959-x.
Peer-Reviewed Original Research
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MeSH Keywords and Concepts
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
Cakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, Lee M, Greaney AM, Yang WS, duBoulay C, Kural MH, Patterson B, Zhong M, Kim J, Bai Y, Min W, Niklason LE, Patra P, Park IH. Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids. Nature Communications 2022, 13: 430. PMID: 35058453, PMCID: PMC8776770, DOI: 10.1038/s41467-022-28043-y.
Peer-Reviewed Original Research
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MeSH Keywords and Concepts
2021
Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience
Raredon MSB, Fisher C, Heerdt PM, Schonberger RB, Nargi A, Nivison S, Fajardo E, Deshpande R, Akhtar S, Greaney AM, Belter J, Raredon T, Zinter J, McKee A, Michalski M, Baevova P, Niklason LE. Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience. Anesthesia & Analgesia 2021, 134: 1094-1105. PMID: 34928890, DOI: 10.1213/ane.0000000000005825.
Peer-Reviewed Original Research
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MeSH Keywords and Concepts
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds
Yuan Y, Leiby KL, Greaney AM, Raredon MSB, Qian H, Schupp JC, Engler AJ, Baevova P, Adams TS, Kural MH, Wang J, Obata T, Yoder MC, Kaminski N, Niklason LE. A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds. Frontiers In Bioengineering And Biotechnology 2021, 9: 760309. PMID: 34869270, PMCID: PMC8640093, DOI: 10.3389/fbioe.2021.760309.
Peer-Reviewed Original Research
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Concepts
Microvascular fluid flow in ex vivo and engineered lungs
Raredon MSB, Engler AJ, Yuan Y, Greaney AM, Niklason LE. Microvascular fluid flow in ex vivo and engineered lungs. Journal Of Applied Physiology 2021, 131: 1444-1459. PMID: 34554016, PMCID: PMC8616606, DOI: 10.1152/japplphysiol.00286.2020.
Peer-Reviewed Original Research
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MeSH Keywords and Concepts
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ORCID
0000-0002-6316-0410
Academic Achievements and Community Involvement
honor Rising Star in Engineering in Health 2023
National AwardCornell University, Columbia University, Johns Hopkins University
Details
honor Convergence Scholars Program at MIT
Other AwardMarble Center for Cancer Nanomedicine and MIT Center for Precision Medicine
Details
honor NIH NRSA F32 Postdoctoral Fellowship Award
National AwardNational Heart, Lung, and Blood Institute
Details
honor Homeward Bound HB3 Cohort
International Award
Details
Get In Touch
Contacts
allison.greaney@yale.edu
Locations
The Anlyan Center
Lab
300 Cedar Street
New Haven, CT 06519
